Outcomes (surgical)

Perinatal and early surgical outcome for the fetus with hypoplastic left heart syndrome: a 5-year single institutional experience.
Rychik J, Szwast A, Natarajan S, Quartermain M, Donaghue DD, Combs J, Gaynor JW, Gruber PJ, Spray TL, Bebbington M, Johnson MP.
Ultrasound Obstet Gynecol. 2010 Oct;36(4):465-70. Review.  PMID: 20499409

Fontan operation in the current era: a 15-year single institution experience.
Hirsch JC, Goldberg C, Bove EL, Salehian S, Lee T, Ohye RG, Devaney EJ.
Ann Surg. 2008 Sep;248(3):402-10.PMID: 18791360

Tricuspid valve repair for hypoplastic left heart syndrome and the failing right ventricle.
Bove EL, Ohye RG, Devaney EJ, Hirsch J.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2007:101-4.PMID: 17434000

Hypoplastic left heart syndrome: consensus and controversies in 2007.
Wernovsky G, Ghanayem N, Ohye RG, Bacha EA, Jacobs JP, Gaynor JW, Tabbutt S.
Cardiol Young. 2007 Sep;17 Suppl 2:75-86. Review.PMID: 18039401

Contemporary results and current strategies in the management of hypoplastic left heart syndrome.
Pigula FA, Vida V, Del Nido P, Bacha E.
Semin Thorac Cardiovasc Surg. 2007 Fall;19(3):238-44. Review.PMID: 17983951

Hypoplastic left heart syndrome with intact or highly restrictive atrial septum: surgical experience from a single center.
Vida VL, Bacha EA, Larrazabal A, Gauvreau K, Thiagaragan R, Fynn-Thompson F, Pigula FA, Mayer JE Jr, del Nido PJ, Tworetzky W, Lock JE, Marshall AC.
Ann Thorac Surg. 2007 Aug;84(2):581-5; discussion 586.PMID: 17643639

Current outcomes and risk factors for the Norwood procedure.
Stasik CN, Gelehrter S, Goldberg CS, Bove EL, Devaney EJ, Ohye RG.
J Thorac Cardiovasc Surg. 2006 Feb;131(2):412-7. Epub 2006 Jan 18. Erratum in: J Thorac Cardiovasc Surg. 2007 Mar;133(3):602. Gelehrter, S [added]. PMID: 16434272

Outcomes of the Fontan procedure using cardiopulmonary bypass with aortic cross-clamping.
Meyer DB, Zamora G, Wernovsky G, Ittenbach RF, Gallagher PR, Tabbutt S, Gruber PJ, Nicolson SC, Gaynor JW, Spray TL.
Ann Thorac Surg. 2006 Nov;82(5):1611-8; discussion 1618-20.PMID: 17062214

Intermediate outcomes after the Fontan procedure in the current era.
Mitchell ME, Ittenbach RF, Gaynor JW, Wernovsky G, Nicolson S, Spray TL.
J Thorac Cardiovasc Surg. 2006 Jan;131(1):172-80. Epub 2005 Dec 5.PMID: 16399309 [PubMed - indexed for MEDLINE]Related citations

Outcomes after the stage I reconstruction comparing the right ventricular to pulmonary artery conduit with the modified Blalock Taussig shunt.
Tabbutt S, Dominguez TE, Ravishankar C, Marino BS, Gruber PJ, Wernovsky G, Gaynor JW, Nicolson SC, Spray TL.
Ann Thorac Surg. 2005 Nov;80(5):1582-90; discussion 1590-1.PMID: 16242421

Late outcomes in patients with surgically treated congenital heart disease.
Schultz AH, Wernovsky G.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2005:145-56. Review.PMID: 15818371

Hypoplastic Left Heart Syndrome (HLHS) Information Page

Selected Medical Journal Abstracts
This web site is not intended as medical advice.  Please consult your physician with any questions you may have regarding your child's condition.

Copyright © 2001-2011 D.L. Hilton-Kamm, all rights reserved.
Here are just a few abstracts found on the PubMed database of recently published studies pertaining to HLHS on surgical outcomes, and for neurological outcomes. These are listed merely as a guide to show what kinds of studies are being done, and to help you ask questions of the surgeons and cardiologists.  We have chosen to list mainly those studies done in the US since that is where the majority of the surgeries take place, and since this is where the more experienced hospitals are.  You will find that success rates vary greatly depending upon how long a hospital has had a program to treat HLHS.

Research:  When researching articles, it is important to note the date, since even just a few year's time makes a huge difference in the outcomes (these are listed with the most recent first).  You can go to the PubMed data base and read the abstracts free, but the full articles are usually offered for a fee and require registration.  You can also look up the full articles for free at a medical library. 
Outcomes (neurological and learning)

Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?
Gaynor JW, Gerdes M, Nord AS, Bernbaum J, Zackai E, Wernovsky G, Clancy RR, Heagerty PJ, Solot CB, McDonald-McGinn D, Jarvik GP.
J Thorac Cardiovasc Surg. 2010 Dec;140(6):1230-7. Epub 2010 Oct 15.PMID: 20951391

Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome.
Tabbutt S, Nord AS, Jarvik GP, Bernbaum J, Wernovsky G, Gerdes M, Zackai E, Clancy RR, Nicolson SC, Spray TL, Gaynor JW.
Pediatrics. 2008 Mar;121(3):476-83.PMID: 18310195

Academic performance and behavioral difficulties after neonatal and infant heart surgery.
Shillingford AJ, Wernovsky G.
Pediatr Clin North Am. 2004 Dec;51(6):1625-39, ix. Review.PMID: 15561177

Neurodevelopmental outcomes in hypoplastic left heart syndrome.
Mahle WT, Wernovsky G.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2004;7:39-47. Review.PMID: 15283351

Neurodevelopmental outcome of patients after the Fontan operation: A comparison between children with hypoplastic left heart syndrome and other functional single ventricle lesions.
Goldberg CS, Schwartz EM, Brunberg JA, Mosca RS, Bove EL, Schork MA, Stetz SP, Cheatham JP, Kulik TJ
J Pediatr 2000 Nov;137(5):646-652
Survivors (2 young women with HLHS who gave birth – amazing development)

Successful pregnancies in two women with hypoplastic left heart syndrome.
Opotowsky AR, Shellenberger D, Dharan V, Paré E, Norwood WI, Webb GD, Donner R.
Congenit Heart Dis. 2010 Sep;5(5):476-81.PMID: 21087437 [PubMed - in process]Related citations